DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...

The replication stutter During replication, DNA polymerases are positioned on each strand of DNA . Using a microscope slide as an anchor, we tethered DNA to a bead and stretched it with a flow of ...

A team of researchers has uncovered a previously unknown mechanism that can disrupt DNA replication at the ends of chromosomes, shedding new light on one of the most fundamental challenges faced by ...